Abstract
It is my purpose in this paper to concentrate upon the status of research which ostensibly is directed toward discovering the etiological factors and the mechanisms underlying palate malformation in man. I shall then attempt, by a brief survey of certain epidemiological information and new knowledge about human embryology, to restate old problems and to offer for your consideration some new hypotheses that might merit investigation. Let me state in advance that I am convinced that much of the research to date, while of importance to general biology, is not directed toward, nor does it have the potentiality of attaining, an understanding of certain unique features of cleft palate development in man.
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